Circles or squares represent deleted TFs or target genes, respectively. Protein-DNA interactions between TFs and the gene promoters they bind are represented as arrows colored blue (bound in -MMS only), orange (+MMS only), or green (both + and -MMS). Genes are colored orange or blue, representing induction or repression in response to MMS. Each binding interaction shown is supported by a deletion-buffering effect. For example, deletion of the transcription factor SWI6 results in lack of expression of DIN7 and DUN1 in response to MMS. In total, 42 binding interactions covering 37 distinct target genes are supported.
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