IDEKER LAB
University of California,San Diego
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| Overview | Tables & data download | Figures: S1, S2, S3, S4, S5, S6, S7, S8 | Additional Figures: 1, 2, 3, 4, 5 | References | ||
Figure S7. Expression of RNR genes and their binding by Crt1p (Rfx1p) in the presence vs absence of MMS | ||
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(A) Distributions of normalized spot intensities (cy3 and cy5 channels) for the four RNR genes in crt1Δ + vs. -MMS over four replicate microarrays (16 spot intensities for each distribution). The wild-type expression levels show an induction of these genes after exposure to MMS while the crt1Δ experiment shows constitutive expression for both + and -MMS.
(B) The binding data show strong evidence for Crt1p binding upstream of RNR2,4 (and marginal evidence for RNR1,3) in nominal growth conditions while binding evidence suggests a lack of Crt1p binding for all RNR genes after exposure to MMS. These data support the induction (by derepression) observed in the first two distributions in (A).
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